Sang Bai Pi TCM v2 (Morus alba (root bark)): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Sang Bai Pi work to clear lung heat?

Sang Bai Pi (Morus alba root bark) contains active compounds including morusin, kuwanon, mulberroside, and sanggenon that exhibit anti-inflammatory and diuretic properties. In Traditional Chinese Medicine theory, it works by draining lung heat downward and promoting urination to reduce edema. The flavonoids help reduce inflammatory markers in lung tissue. Evidence Level: C (preliminary clinical evidence). The cooling nature of the bark helps clear excess heat from the lung meridian.

Does Sang Bai Pi interact with diabetes medications?

Sang Bai Pi may interact with antidiabetic medications due to its hypoglycemic effects. The root bark contains compounds that can lower blood glucose levels, potentially enhancing the effects of insulin or oral hypoglycemic drugs. Patients taking diabetes medications should monitor blood sugar closely and consult a healthcare provider before use. Due to its diuretic properties, it may also interact with diuretic medications and affect electrolyte balance. Evidence Level: C.

What is the recommended dosage for Sang Bai Pi?

The standard adult dosage for Sang Bai Pi is 6-12 grams daily when prepared as a decoction. The dried root bark is typically boiled in water and consumed as a tea. Dosage may vary based on individual condition, age, and constitution. For lung heat conditions with cough or edema, practitioners may adjust the amount within this range. It should not be used long-term without professional guidance. Evidence Level: Traditional use. Always follow a qualified TCM practitioner's recommendations.

Is Sang Bai Pi safe to take during pregnancy?

Sang Bai Pi is generally considered safe during pregnancy when used appropriately under professional guidance. Traditional Chinese Medicine sources indicate it does not have strong contraindications for pregnant women. However, as with any herbal medicine during pregnancy, it should only be used when specifically indicated and prescribed by a qualified practitioner. The diuretic effects should be monitored carefully. Evidence Level: Traditional use. Pregnant women should always consult their healthcare provider before starting any herbal treatment.

What conditions does Sang Bai Pi treat in Traditional Chinese Medicine?

Sang Bai Pi is primarily used in TCM to treat lung heat cough, wheezing, edema, and hypertension. It excels at draining lung heat and promoting urination to reduce fluid retention. The root bark is particularly effective for coughs with yellow phlegm, asthmatic breathing with heat signs, and facial or limb edema. It also helps lower elevated blood pressure through its diuretic action. Evidence Level: C. Practitioners often combine it with other herbs based on individual pattern diagnosis.

Who should not take Sang Bai Pi?

Sang Bai Pi is contraindicated for individuals with lung cold cough or spleen deficiency patterns. Those with cold-type coughs characterized by clear or white phlegm, and patients with weak digestion, bloating, or loose stools should avoid this cooling herb. Common side effects may include mild gastrointestinal upset and potential drops in blood sugar due to its hypoglycemic properties. Evidence Level: Traditional use. Patients with diabetes should use caution and monitor glucose levels.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 22 articles PubMed · modèle : gemma4:31b

Résumé

Sang Bai Pi (Morus alba root bark) is used in traditional Chinese medicine to treat respiratory infections and colds [PMID:40840729, PMID:38143489], demonstrating broad antibacterial, anti-inflammatory, and neuroprotective properties [PMID:40840729, PMID:40542887].

Contexte

Sang Bai Pi is the root bark of the white mulberry tree, Morus alba L. [PMID:40840729, PMID:30335608].

Usages traditionnels

It has been used for centuries in traditional Chinese medicine to treat colds, respiratory infections [PMID:40840729, PMID:38143489], headaches, as a diuretic, expectorant, and anti-diabetic agent [PMID:22472211].

Composés actifs

Bioactive constituents include flavonoids such as Sanggenol L [PMID:40542887], morusinol [PMID:29433688, PMID:22472211], and kuwanon E [PMID:29433688]; Diels-Alder-type adducts (MDAAs) including sanggenons C, D, G, and O [PMID:39252692, PMID:22294264, PMID:29332820]; and farnesylated 2-arylbenzofurans such as morusalfurans B and C [PMID:32978714].

Mécanisme d'action

Mechanisms include inhibition of the HMGB1/TLR4/NF-κB signaling pathway [PMID:40542887], activation of the PI3K/Akt/Nrf2 signaling pathway [PMID:42205897], and modulation of GABA(A) receptors [PMID:22294264]. It also exhibits inhibitory effects on α-glucosidase [PMID:29332820], protein tyrosine phosphatase 1B (PTP1B) [PMID:32978714], and human monoamine oxidase (hMAO) [PMID:31835621].

Preuves cliniques

Preuve DBacterial Infections (MRSA/Enterococcus)

Prenylflavonoids and extracts show antibacterial activity against MRSA and Enterococcus spp. [PMID:29433688, PMID:40840729]

Preuve DCerebral Ischemia-Reperfusion Damage

Sanggenol L prevented brain injury and reduced infarct volume in rat models [PMID:40542887]

Preuve DPancreatitis

Methanolic extract (MEMARB) reduced serum amylase, lipase, and inflammatory markers in rat models [PMID:30335608, PMID:30302330]

Preuve DDiabetes

High-dose alcohol extract (600 mg/kg) significantly reduced glucose and increased insulin levels in STZ-induced diabetic rats [PMID:15885940]

Preuve DOsteoarthritis

Water extracts alleviated osteoarthritis symptoms and prevented reduction of bone mineral density in testosterone-deficient rats [PMID:33371279]

Preuve DCardiovascular/Thrombosis

Morusinol inhibited collagen- and arachidonic acid-induced platelet aggregation and arterial thrombus formation [PMID:22472211]

Sécurité et effets indésirables

An acute toxicity study in BALB/c mice was conducted to determine the maximum tolerated dose (MTD) of a standardized extract (MA60) [PMID:38143489].

Synthèse des preuves

The current evidence is primarily based on in vitro studies and animal models (Level D), demonstrating significant potential for anti-infective, anti-inflammatory, and neuroprotective applications.

Sources PubMed

1.PMID: 40840729 (2025) — Sanggenon C - A novel anti-enterococcal agent from Morus alba root bark. · Journal of ethnopharmacology
2.PMID: 40542887 (2025) — Sanggenol L inhibits the HMGB1/TLR4/NF-κB signaling pathway to prevent cerebral ischemia-reperfusion damage. · Journal of molecular histology
3.PMID: 39252692 (2024) — Biopharmaceutical profiling of anti-infective sanggenons from Morus alba root bark for inhalation administration. · International journal of pharmaceutics: X
4.PMID: 29433688 (2018) — Synergism of prenylflavonoids from Morus alba root bark against clinical MRSA isolates. · Phytomedicine : international journal of phytotherapy and phytopharmacology
5.PMID: 31610262 (2020) — Multiple In vitro biological effects of phenolic compounds from Morus alba root bark.

Sang Bai Pi TCM v2

Sources et citations

Calculer une dose sûre de Sang Bai Pi TCM v2

Sang Bai Pi

Jatropha gossypiifolia

Crescentia Cujete

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Sang Bai Pi TCM v2

Sources et citations

Calculer une dose sûre de Sang Bai Pi TCM v2

Plantes associées

Sang Bai Pi

Jatropha gossypiifolia

Crescentia Cujete

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales