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PubMed · Antimicrobial Mechanism and Identification of the Proteins Mediated by Extracts from <i>Asphaltum punjabianum</i> and <i>Myrtus communis</i>. (2020)
Révisé par : HerbAlly Editorial Team, Medical herbalists and healthcare professionals
Dernière mise à jour : April 2026
Calculer une dose sûre de Shilajit Mineral
Calculateur gratuit de posologie — doses adultes et enfants selon le poids.
Shilajit works primarily through its fulvic acid and dibenzo-alpha-pyrone content, which enhance mitochondrial function and cellular energy production. Fulvic acid acts as a carrier molecule, improving the bioavailability of minerals and nutrients at the cellular level. These compounds help optimize the electron transport chain in mitochondria, supporting ATP production. Additionally, shilajit provides over 80 trace minerals in ionic form. This mechanism explains its traditional use as a rejuvenative tonic and its researched effects on fatigue, cognitive function, and physical performance. Evidence level: C.
Does shilajit interact with any medications?
Shilajit has limited documented drug interactions, but caution is advised with certain medications. Due to its effects on testosterone levels, it may theoretically interact with hormone therapies or medications affecting the endocrine system. Those taking medications for gout or high uric acid should avoid shilajit, as it can elevate uric acid levels. Shilajit may also enhance iron absorption, potentially affecting iron-chelating medications. Always consult a healthcare provider before combining shilajit with prescription medications, particularly hormonal treatments or drugs affecting mineral metabolism. Evidence level: Traditional/C.
How much shilajit should I take daily?
The recommended adult dosage is 300-500mg of purified shilajit resin or 100mg of standardized extract daily. Traditional use typically divides this into two doses taken with warm water or milk. Standardized extracts are often dosed at 100mg to provide consistent fulvic acid content. Start with lower doses to assess tolerance, as shilajit can cause mild gastrointestinal upset in some individuals. Quality matters significantly—only use purified, tested products to avoid heavy metal contamination. Evidence level: Traditional/C.
Is shilajit safe during pregnancy?
Shilajit is not recommended during pregnancy or breastfeeding. The safety profile for pregnant women has not been established through clinical research, and traditional Ayurvedic texts advise against its use during this time. Shilajit's effects on hormones, particularly testosterone modulation, pose theoretical risks to fetal development. Additionally, the mineral content and potential for heavy metal contamination in unpurified products present unacceptable risks. Pregnant and nursing mothers should avoid shilajit and consult their healthcare provider for safe alternatives. Evidence level: Traditional.
Does shilajit increase testosterone levels?
Research suggests shilajit may support healthy testosterone levels in men, particularly those with low baseline levels. Studies indicate improvements in both total and free testosterone after regular supplementation. Shilajit also appears to improve sperm quality, including count and motility, likely due to its antioxidant properties and mineral content. These effects support its traditional use as a male reproductive tonic and aphrodisiac in Ayurveda. However, evidence is preliminary (Level C), and individuals with hormonal conditions should consult a healthcare provider before use.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Shilajit is a natural mineral exudation used in traditional medicine as a rejuvenator and adaptogen [PMID:17295385], exhibiting antioxidant, anti-inflammatory, and immunomodulatory properties [PMID:23733436].
Contexte
Shilajit (Asphaltum punjabianum) is a pale-brown to blackish-brown exudation of variable consistency that leaks from rock layers in mountain ranges, particularly the Himalayas and Hindukush [PMID:17295385, PMID:23668027]. It is composed of a complex mixture of organic humic substances, plant and microbial metabolites [PMID:17295385], and may contain at least 85 minerals in ionic form [PMID:26875561].
Usages traditionnels
Used for thousands of years as a rejuvenator ('rasayana'), adaptogen, and 'revitalizer' to enhance physical performance and relieve fatigue [PMID:17295385, PMID:21530631, PMID:23733436]. It is traditionally used for bone fractures, inflammatory ailments, and male reproductive health issues [PMID:23668027, PMID:29947420, PMID:32310691].
Composés actifs
Key constituents include fulvic acid, humic acid, and dibenzo-α-pyrones [PMID:23733436, PMID:23668027]. Other identified components include flavonoids, terpenoids, saponins, tannins, alkaloids, steroids, and glycosides [PMID:33502921].
Mécanisme d'action
Shilajit exhibits antioxidant and anti-inflammatory activities [PMID:23733436]. It has been shown to induce dose-dependent inward currents by activating strychnine-sensitive glycine receptors on preoptic hypothalamic neurons [PMID:26875561] and may modulate the NF-κB/AKT/Caspase-3 axis for hepatoprotection [PMID:40957543].
Preuves cliniques
Preuve BMale Androgenic Hormones
Purified Shilajit (250 mg twice daily for 90 days) significantly increased total testosterone, free testosterone, and DHEAS in healthy volunteers aged 45-55 [PMID:26395129].
Preuve BPostmenopausal Osteopenia
Standardized aqueous extract of shilajit dose-dependently attenuated bone mineral density (BMD) loss in the lumbar spine and femoral neck over 48 weeks [PMID:35933897].
Preuve BTibia Fracture Repair
Evaluated for efficacy and safety in tibia fracture healing in a randomized double-blinded trial [PMID:32310691].
Sécurité et effets indésirables
The safety of shilajit is reported as well documented based on animal and human studies [PMID:23733436]. However, it contains approximately 65 heavy metals, including toxic metals such as Pb, As, Cd, and Hg, though humic substances may actively detoxify around 12 of these [PMID:38393486].
Synthèse des preuves
Evidence consists of a mix of randomized controlled trials (B) for testosterone and bone density, and several reviews (C) and animal/in vitro studies (D) supporting its antioxidant and anti-inflammatory properties.
Sources PubMed
1.PMID: 26395129 (2016) — Clinical evaluation of purified Shilajit on testosterone levels in healthy volunteers. · Andrologia
2.PMID: 23733436 (2014) — Safety and efficacy of shilajit (mumie, moomiyo). · Phytotherapy research : PTR
3.PMID: 17295385 (2007) — Shilajit: a review. · Phytotherapy research : PTR
4.PMID: 38133965 (2025) — A Comprehensive Review on Shilajit: What We Know about Its Chemical Composition. · Critical reviews in analytical chemistry
5.PMID: 35933897 (2022) — Shilajit extract reduces oxidative stress, inflammation, and bone loss to dose-dependently preserve bone mineral density in postmenopausal women with osteopenia: A randomized, double-blind, placebo-controlled trial. · Phytomedicine : international journal of phytotherapy and phytopharmacology
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 37697053 (2024) — Do "testosterone boosters" really increase serum total testosterone? A systematic review. · International journal of impotence research
7.PMID: 39142489 (2024) — Electrophoretically deposited Asphaltum punjabianum (Shilajit) coatings on polyvinylalcohol/carboxymethylcellulose hydrogels. · International journal of biological macromolecules
8.PMID: 21530631 (2011) — Review on shilajit used in traditional Indian medicine. · Journal of ethnopharmacology
9.PMID: 38393486 (2024) — Hazardous or Advantageous: Uncovering the Roles of Heavy Metals and Humic Substances in Shilajit (Phyto-mineral) with Emphasis on Heavy Metals Toxicity and Their Detoxification Mechanisms. · Biological trace element research
11.PMID: 33818003 (2021) — Treatment effects of Shilajit on aspirin-induced gastric lesions in rats. · Physiological reports
12.PMID: 24448712 (2014) — Cardioprotective effect of mumie (shilajit) on experimentally induced myocardial injury. · Cardiovascular toxicology
13.PMID: 36153551 (2022) — Accelerating effect of Shilajit on osteogenic property of adipose-derived mesenchymal stem cells (ASCs). · Journal of orthopaedic surgery and research
14.PMID: 32310691 (2020) — Efficacy of Momiai in Tibia Fracture Repair: A Randomized Double-Blinded Placebo-Controlled Clinical Trial. · Journal of alternative and complementary medicine (New York, N.Y.)
15.PMID: 33502921 (2021) — Asphaltum Improves the Post-thaw Quality and Antioxidant Status of Nili Ravi Buffalo Bull Sperm. · Biopreservation and biobanking
16.PMID: 40957543 (2026) — Shilajit extract (ZhaXun) protects against acetaminophen-induced liver injury via modulation of the NF-κB/AKT/Caspase-3 axis. · Journal of ethnopharmacology
17.PMID: 10919969 (2000) — Selected herbals and human exercise performance. · The American journal of clinical nutrition
18.PMID: 41640940 (2026) — Pre-clinical Evaluation of Shilajit in Cancer: A Systematic Review. · Cureus
19.PMID: 29947420 (2018) — Profertility effects of Shilajit on cadmium-induced infertility in male mice. · Andrologia
20.PMID: 32083445 (2020) — Hepatoprotective effects of Shilajit on high fat-diet induced non-alcoholic fatty liver disease (NAFLD) in rats. · Hormone molecular biology and clinical investigation
21.PMID: 12926866 (2003) — Characterization and biological activities of humic substances from mumie. · Journal of agricultural and food chemistry
22.PMID: 26875561 (2016) — Activation of Strychnine-Sensitive Glycine Receptors by Shilajit on Preoptic Hypothalamic Neurons of Juvenile Mice. · The Chinese journal of physiology
23.PMID: 33065073 (2021) — Antiviral activity of natural humic substances and shilajit materials against HIV-1: Relation to structure. · Environmental research
24.PMID: 37846531 (2023) — Investigation of Neuroprotective Effect of Shilajit Extract in Experimental Head Trauma Model Created in Rats. · Turkish neurosurgery
25.PMID: 32612671 (2020) — Mechanisms of generation and exudation of Tibetan medicine Shilajit (Zhaxun). · Chinese medicine
26.PMID: 23668027 (2013) — [Research advances of Tasmayi]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
27.PMID: 2345464 (1990) — Antiulcerogenic and antiinflammatory studies with shilajit. · Journal of ethnopharmacology
28.PMID: 35258780 (2022) — Protective Roles of Shilajit in Modulating Resistin, Adiponectin, and Cytokines in Rats with Non-alcoholic Fatty Liver Disease. · Chinese journal of integrative medicine
29.PMID: 39121783 (2024) — Shilajit mitigates chemotherapeutic drug-induced testicular toxicity: Study on testicular germ cell dynamics, steroidogenesis modulation, and Nrf-2/Keap-1 signaling. · Journal of Ayurveda and integrative medicine