Wild Celery (Apium graveolens var. secalinum): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does wild celery work for gout relief?

Wild celery contains active compounds including apigenin, luteolin, and phthalides that may help reduce inflammation and support uric acid excretion. These compounds work by inhibiting inflammatory pathways in the body, while the herb's natural diuretic properties may help flush excess uric acid through the kidneys. Sedanolide contributes additional anti-inflammatory effects. Evidence level C indicates that while these mechanisms are supported by preliminary research and traditional use, more clinical trials are needed to fully establish effectiveness for gout.

Does wild celery interact with any medications?

Wild celery may interact with diuretics, blood thinners, and lithium. Its natural diuretic properties can enhance the effects of prescription diuretic medications, potentially causing dehydration or electrolyte imbalances. The herb may also affect blood clotting, so those taking anticoagulants like warfarin should exercise caution. Additionally, wild celery could alter how the liver processes certain medications. Those with kidney disease should avoid wild celery entirely. Always consult a healthcare provider before combining wild celery with prescription medications.

What is the recommended dosage for wild celery?

The typical adult dosage for wild celery is 2-4 grams of dried herb or 2-4 milliliters of tincture, taken up to three times daily. This dosage is based on traditional herbalist recommendations rather than standardized clinical trials. Start with the lower dosage range to assess individual tolerance. Dosage may vary depending on the specific preparation and condition being addressed. Consult a qualified healthcare practitioner for personalized dosing guidance, particularly if you have underlying health conditions.

Is wild celery safe to take during pregnancy?

Wild celery is considered unsafe during pregnancy and should be avoided. The herb contains compounds that may stimulate uterine contractions and potentially affect pregnancy outcomes. Evidence level C supports this contraindication based on traditional knowledge and pharmacological understanding. Women who are breastfeeding should also avoid wild celery due to insufficient safety data. Those with celery allergies or kidney disease should not use wild celery preparations. Always consult a healthcare provider before using any herbal supplements during pregnancy.

What are the side effects of wild celery?

Common side effects of wild celery include photosensitivity, allergic reactions, and digestive upset. The herb contains psoralens that can increase skin sensitivity to sunlight, potentially causing rashes or sunburn with exposure. Those with known celery allergies may experience severe reactions including difficulty breathing. Digestive symptoms may include nausea, bloating, or diarrhea. People with kidney disease should avoid wild celery as it may worsen kidney function. Discontinue use immediately if any adverse reactions occur and seek medical attention for severe symptoms.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Wild celery refers to several species, including Smyrnium olusatrum and Kelussia odoratissima, which exhibit various biological activities including antiproliferative, neuroprotective, and anti-inflammatory effects [PMID:24924290, 26304411, 25446599].

Contexte

The term 'wild celery' is applied to multiple botanical entities: Smyrnium olusatrum (a biennial herb used since the Roman Empire) [PMID:22980882], Kelussia odoratissima (a medicinal species native to Iran) [PMID:36365418], and Apium graveolens var. secalinum (annual smallage) [PMID:24193461]. It is also used to describe the aquatic macrophyte Vallisneria americana [PMID:21564928].

Usages traditionnels

Smyrnium olusatrum was used for centuries as an edible vegetable [PMID:22980882]. Kelussia odoratissima leaves and stems are traditionally used to treat hypertension and inflammation [PMID:25446599].

Composés actifs

Smyrnium olusatrum is a rich source of furanosesquiterpenoids, primarily isofuranodiene [PMID:22980882, 26304411]. Other identified compounds in various 'wild celery' species include curzerene, germacrone, 4'-geranyloxyferulic acid, and umbelliferone [PMID:24924290, 27916506].

Mécanisme d'action

Isofuranodiene has been shown to induce apoptosis in human colon carcinoma cells [PMID:24924290] and stimulate neuritogenesis in rat neuronal PC-12 cells [PMID:26304411]. In animal models of ischemic stroke, it reduced inflammatory cytokines IL-1β and TNF-α and inhibited the expression of pNF-κB/NF-κB [PMID:33918587].

Preuves cliniques

Preuve DColon Carcinoma

Essential oil and isofuranodiene from S. olusatrum induced apoptosis in HCT116 cells (IC50 10.71 and 15.06 μg/ml) [PMID:24924290].

Preuve DIschemic Stroke (Rat Model)

Pre-treatment with isofuranodiene (10 mg/kg i.p.) reduced inflammatory cytokines and improved neurological severity scores [PMID:33918587].

Preuve DLiver Injury (Rat Model)

Oral administration of isofuranodiene (20 and 50 mg/kg) inhibited GalN/LPS-induced serum elevation of AST and ALT [PMID:25978596].

Preuve DPulmonary Hypertension (Broiler Chickens)

Dietary inclusion of K. odoratissima (0.75%) improved body weight gain and over-expressed inducible nitric oxide synthase in the heart [PMID:25446599].

Preuve BAxial Undifferentiated Spondyloarthritis

Wild celery was used as one component (10g) of the Qiangji Recipe in an adjunctive treatment study [PMID:25790672].

Preuve DPain and Inflammation (Animal Model)

Synthèse des preuves

The evidence is primarily based on in vitro studies and animal models (Level D), with one clinical trial (Level B) where wild celery was part of a multi-herb recipe. Most specific pharmacological data pertains to the compound isofuranodiene from Smyrnium olusatrum.

Sources PubMed

1.PMID: 24193461 (1993) — Identification and classification of celery cultivars with RAPD markers. · TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik
2.PMID: 39707837 (2025) — Genome of root celery and population genomic analysis reveal the complex breeding history of celery. · Plant biotechnology journal
3.PMID: 37222714 (2023) — Classification of the mechanisms by which cardiotoxic plant poisons exert their effects. · Postgraduate medical journal
4.PMID: 27916506 (2017) — Quantification of biologically active O-prenylated and unprenylated phenylpropanoids in dill (Anethum graveolens), anise (Pimpinella anisum), and wild celery (Angelica archangelica). · Journal of pharmaceutical and biomedical analysis
5.PMID: 24924290 (2014) — Wild celery (Smyrnium olusatrum L.) oil and isofuranodiene induce apoptosis in human colon carcinoma cells.

Wild Celery

Sources et citations

Calculer une dose sûre de Wild Celery

Kunzea Ambigua

Dioscorea nipponica

Ribes nigrum

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Wild Celery

Sources et citations

Calculer une dose sûre de Wild Celery

Plantes associées

Kunzea Ambigua

Dioscorea nipponica

Ribes nigrum

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Synthèse des preuves

Sources PubMed

Sources gouvernementales