Wild Chrysanthemum (Chrysanthemum indicum): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Wild Chrysanthemum work to clear heat and toxins?

Wild Chrysanthemum contains active compounds including luteolin, apigenin, chlorogenic acid, and borneol that demonstrate anti-inflammatory and antibacterial properties. These flavonoids and phenolic acids work by inhibiting pro-inflammatory cytokines and oxidative stress pathways. In Traditional Chinese Medicine, this herb is considered stronger than regular Chrysanthemum (Ju Hua) for clearing heat and toxins from the body, making it effective for infections and inflammatory conditions. Evidence level: C.

Can Wild Chrysanthemum interact with blood pressure medications?

Wild Chrysanthemum has documented antihypertensive properties and may potentially enhance the effects of blood pressure lowering medications. Patients taking antihypertensive drugs should consult a healthcare provider before using this herb, as combined use could cause hypotension (blood pressure that is too low). Limited clinical data exists on specific drug interactions. Evidence level: C. Always inform your healthcare provider about all herbal supplements you are taking.

What is the recommended dosage for Wild Chrysanthemum?

The standard adult dosage for Wild Chrysanthemum is 9-15 grams of dried herb, typically prepared as a decoction. This herb should not be used for prolonged periods due to its strong cooling properties, which may damage the spleen and stomach. Dosage may vary based on the specific condition being treated and individual constitution. Consult a qualified herbalist for personalized dosing recommendations. Evidence level: Traditional.

Is Wild Chrysanthemum safe during pregnancy?

Wild Chrysanthemum is contraindicated during pregnancy and should be avoided. This herb has strong heat-clearing and toxin-clearing properties that may stimulate uterine contractions or affect fetal development. Women who are pregnant, nursing, or attempting to conceive should not use this herb. Evidence level: Traditional. Always consult a qualified healthcare provider before using any herbal supplements during pregnancy.

What conditions does Wild Chrysanthemum treat?

Wild Chrysanthemum is traditionally used to treat carbuncles, abscesses, sore throat, and hypertension. It clears heat and toxins from the body and demonstrates antibacterial properties against various pathogens. This herb is considered more potent than regular Chrysanthemum (Ju Hua) for addressing toxic heat conditions. Evidence level: C. It is contraindicated for individuals with cold spleen and stomach conditions, and may cause gastrointestinal discomfort with excessive use.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Wild Chrysanthemum (Chrysanthemum indicum L.) is a perennial plant of the Asteraceae family used traditionally in Asia for its anti-inflammatory, antioxidant, and hepatoprotective properties [PMID:39624846, 39407539, 32431180].

Contexte

Chrysanthemum indicum L. is a perennial plant belonging to the Asteraceae (or Compositae) family, native to Eastern Asia [PMID:39624846, 32431180, 37662149]. It is recognized as a traditional edible medicinal herb used in China for over 2000 years [PMID:39788286, 32431180].

Usages traditionnels

Traditionally used in Asia for the treatment of headaches, colds, rhinitis [PMID:39624846], as well as pemphigus, swelling, pain, and scrofula [PMID:32431180]. It is also used in the southwest plateau region of China to prevent ultraviolet-induced skin damage [PMID:25052044].

Composés actifs

The plant contains over 190 chemical constituents, including flavonoids (such as luteolin, apigenin, and kaempferol-3-O-glucoside), terpenoids (including guaianolide sesquiterpenoids and chrysanthemol), phenylpropanoids, and phenolic acids [PMID:32431180, 40733262, 32603195, 11407809, 34368979]. Specific bioactive compounds include linarin [PMID:39908585] and handelin [PMID:38009816].

Mécanisme d'action

Mechanisms include the inhibition of nitric oxide (NO) and TNF-α production [PMID:25497988, 32603195], downregulation of COX-2 and iNOS proteins [PMID:25497988], and modulation of Nrf2/Keap1 and TLR4/NF-κB signaling pathways [PMID:39908585]. It may also inhibit mitotic clonal expansion in preadipocytes via the Akt and ERK1/2 signaling pathways [PMID:34368979] and reduce UVB-triggered ERK1/2 and p38 MAPK phosphorylation [PMID:25052044].

Preuves cliniques

Preuve DCancer Cachexia (Muscle Atrophy)

C. indicum improved loss of body weight, impaired glucose tolerance, and inhibited muscle protein degradation factors MAFbx and MuRF1 in mice [PMID:39624846].

Preuve BSkin Hyperpigmentation

A 0.5% water extract cosmetic cream was evaluated in human volunteers; extracts dose-dependently inhibited mushroom tyrosinase activity [PMID:26786567].

Preuve CGout

C. indicum was identified as having high xanthine oxidase inhibitory activity (>85%) [PMID:29628890].

Preuve DHyperuricemic Nephropathy

Linarin, a principal constituent, attenuated hyperuricemic nephropathy in mouse models [PMID:39908585].

Preuve DHepatic Steatosis (NAFLD)

Dimeric guaianolide sesquiterpenoids from the flowers ameliorate hepatic steatosis by mitigating SIRT1-mediated lipid accumulation and ferroptosis [PMID:39788286].

Synthèse des preuves

The current evidence is primarily based on in vitro studies, animal models (mice, C. elegans), and limited human cosmetic trials. There is strong preclinical evidence for anti-inflammatory and antioxidant activities, but high-level clinical trial data (RCTs) for systemic therapeutic use are lacking.

Sources PubMed

1.PMID: 38009816 (2024) — Handelin alleviates cachexia- and aging-induced skeletal muscle atrophy by improving protein homeostasis and inhibiting inflammation. · Journal of cachexia, sarcopenia and muscle
2.PMID: 39788286 (2025) — Dimeric guaianolide sesquiterpenoids from the flowers of Chrysanthemum indicum ameliorate hepatic steatosis through mitigating SIRT1-mediated lipid accumulation and ferroptosis. · Journal of advanced research
3.PMID: 39908585 (2025) — Linarin attenuates hyperuricemic nephropathy by modulating Nrf2/Keap1 and TLR4/NF-κB signaling pathways: Linarin attenuates hyperuricemic nephropathy. · Phytomedicine : international journal of phytotherapy and phytopharmacology
4.PMID: 39624846 (2024) — Chrysanthemum indicum L. ameliorates muscle atrophy by improving glucose tolerance in CT26-induced cancer cachexia. · Frontiers in pharmacology
5.PMID: 29628890

Wild Chrysanthemum

Sources et citations

Calculer une dose sûre de Wild Chrysanthemum

Malvaviscus arboreus

Monk Fruit

Da Qing Ye

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Wild Chrysanthemum

Sources et citations

Calculer une dose sûre de Wild Chrysanthemum

Plantes associées

Malvaviscus arboreus

Monk Fruit

Da Qing Ye

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Synthèse des preuves

Sources PubMed

Sources gouvernementales