This product is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration.
Petasites hybridus
This herb is NOT recommended during pregnancy due to potential risks to the developing fetus.
This herb is NOT recommended while breastfeeding as effects on infants are unknown.
Consult your healthcare provider before use.
This herb may interact with medications you are taking. Review the interactions table below and consult your healthcare provider before use.
Butterbur is a perennial plant native to Europe and parts of Asia, used since ancient times for plague, fever, and respiratory conditions. Modern clinical trials have established it as an effective treatment for migraine prevention and allergic rhinitis. Only PA-free (pyrrolizidine alkaloid-free) products should be used.
Butterbur is a perennial plant native to Europe and parts of Asia, used since ancient times for plague, fever, and respiratory conditions. Modern clinical trials have established it as an effective treatment for migraine prevention and allergic rhinitis. Only PA-free (pyrrolizidine alkaloid-free) products should be used. Key active compounds include Petasin, Isopetasin, Oxopetasin.
Petasin, along with Isopetasin and Oxopetasin, are the primary bioactive compounds in Butterbur. The specific pharmacological pathways require further study, though traditional use supports its efficacy.
Migraine prevention
Supported by clinical evidence; more large-scale trials would strengthen findings
Allergic rhinitis (hay fever)
Supported by clinical evidence; more large-scale trials would strengthen findings
Asthma
Limited clinical evidence; primarily supported by traditional use and preliminary studies
Headache prevention
Limited clinical evidence; primarily supported by traditional use and preliminary studies
Urinary spasms
Limited clinical evidence; primarily supported by traditional use and preliminary studies
Plague treatment
Based on traditional use; clinical evidence limited
Fever reduction
Based on traditional use; clinical evidence limited
Headache relief
Based on traditional use; clinical evidence limited
| Drug | Severity | Description |
|---|---|---|
| CYP3A4 substrates | Mild | Butterbur may inhibit CYP3A4 enzyme, potentially increasing blood levels of drugs metabolized by this pathway. |
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