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Glycyrrhiza glabra
Licorice root is one of the most widely used herbs in Traditional Chinese Medicine, appearing in numerous classical formulas. It has been used for over 4,000 years for respiratory, digestive, and adrenal support. Glycyrrhizin, its primary active compound, is 50 times sweeter than sucrose.
| Drug | Severity | Description |
|---|---|---|
| Hydrochlorothiazide (HCTZ) | severe | Licorice may worsen potassium loss caused by thiazide diuretics, potentially leading to dangerous hypokalemia, cardiac arrhythmias, and muscle weakness. |
| Furosemide (Lasix) | severe | Licorice combined with loop diuretics can cause severe potassium depletion and dangerous hypokalemia. |
| Digoxin | severe | Licorice-induced hypokalemia can increase sensitivity to digoxin toxicity, potentially causing dangerous cardiac arrhythmias. |
| Spironolactone | severe | Licorice may counteract the effects of spironolactone, reducing its blood pressure-lowering and potassium-sparing effects. |
| Antihypertensive medications (general) | moderate | Licorice root can cause sodium retention and potassium loss, raising blood pressure and counteracting antihypertensive medication effects. |