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Glycyrrhiza glabra
This herb is NOT recommended during pregnancy due to potential risks to the developing fetus.
This herb is NOT recommended while breastfeeding as effects on infants are unknown.
Consult your healthcare provider before use.
This herb may interact with medications you are taking. Review the interactions table below and consult your healthcare provider before use.
Licorice root is one of the most widely used herbs in Traditional Chinese Medicine, appearing in numerous classical formulas. It has been used for over 4,000 years for respiratory, digestive, and adrenal support. Glycyrrhizin, its primary active compound, is 50 times sweeter than sucrose.
Licorice root is one of the most widely used herbs in Traditional Chinese Medicine, appearing in numerous classical formulas. It has been used for over 4,000 years for respiratory, digestive, and adrenal support. Glycyrrhizin, its primary active compound, is 50 times sweeter than sucrose. Key active compounds include Glycyrrhizin, Glabridin, Liquiritigenin.
Glycyrrhizin, along with Glabridin and Liquiritigenin, are the primary bioactive compounds in Licorice Root. The specific pharmacological pathways require further study, though traditional use supports its efficacy.
Peptic ulcer support
Supported by clinical evidence; more large-scale trials would strengthen findings
Adrenal fatigue
Supported by clinical evidence; more large-scale trials would strengthen findings
Sore throat and cough
Limited clinical evidence; primarily supported by traditional use and preliminary studies
Hepatitis C support
Limited clinical evidence; primarily supported by traditional use and preliminary studies
Eczema (topical)
Limited clinical evidence; primarily supported by traditional use and preliminary studies
Sore throat remedy
Based on traditional use; clinical evidence limited
Cough suppressant
Based on traditional use; clinical evidence limited
Digestive aid
Based on traditional use; clinical evidence limited
| Drug | Severity | Description |
|---|---|---|
| Spironolactone | Severe | Licorice may counteract the effects of spironolactone, reducing its blood pressure-lowering and potassium-sparing effects. |
| Antihypertensive medications (general) | Moderate | Licorice root can cause sodium retention and potassium loss, raising blood pressure and counteracting antihypertensive medication effects. |
| Digoxin | Severe | Licorice-induced hypokalemia can increase sensitivity to digoxin toxicity, potentially causing dangerous cardiac arrhythmias. |
| Hydrochlorothiazide (HCTZ) | Severe | Licorice may worsen potassium loss caused by thiazide diuretics, potentially leading to dangerous hypokalemia, cardiac arrhythmias, and muscle weakness. |
| Furosemide (Lasix) | Severe | Licorice combined with loop diuretics can cause severe potassium depletion and dangerous hypokalemia. |
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