Maca (Lepidium meyenii): Benefits, Dosage, Safety & Evidence

What is a herb–drug interaction?

A herb–drug interaction happens when a plant or supplement changes how a medication works in your body — making it stronger, weaker, or more likely to cause harm. Herbs contain active compounds that can speed up or slow down the enzymes and transporters your body uses to process drugs.

Why it matters

St. John's Wort can make birth control, antidepressants, and blood thinners less effective.

Garlic can increase bleeding risk with warfarin and other blood thinners (also ginkgo, ginger, and turmeric).

Kava can amplify sedation when taken with anxiety or sleep medications (also valerian).

The risk is highest for older adults, anyone taking several medications, and people with chronic conditions.

Always tell your doctor and pharmacist about every herb and supplement you take — and check below before combining.

Known Drug Interactions (1)

1 Moderate

Drug	Severity	Description
Hormone replacement therapy	Moderate	Maca may modulate hormonal levels and potentially interact with hormone replacement therapy.

This list reflects a curated subset of documented interactions and is not exhaustive. The absence of a drug here is not proof that it is safe to combine. Always confirm with a pharmacist or healthcare provider.

Frequently asked questions

How does maca work to balance hormones?

Maca does not contain hormones itself but is classified as an adaptogen that supports the endocrine system. Its primary mechanism involves unique compounds called macamides and macaenes, which are thought to act on the hypothalamus-pituitary-adrenal (HPA) axis. By modulating the body's stress response and signaling pathways, maca helps regulate the production of hormones like estrogen, testosterone, and progesterone, promoting balance without directly introducing synthetic hormones into the body.

Does maca interact with any medications?

Maca has no well-documented severe drug interactions, but caution is advised for individuals on hormone therapies. Because maca influences hormonal pathways, it may theoretically interfere with hormone replacement therapy (HRT) or birth control pills. Additionally, those taking thyroid medication should consult a physician, as maca contains goitrogens that may interfere with thyroid function, particularly in those with iodine deficiency.

Is maca safe to take during pregnancy?

Maca is generally considered unsafe during pregnancy and breastfeeding. While traditionally used to enhance fertility, there is insufficient clinical safety data to support its use during gestation. Because maca exerts hormonal effects and contains glucosinolates that can affect thyroid function, pregnant women are advised to avoid supplementation unless specifically directed by a qualified healthcare provider.

What is the recommended daily dosage for maca root?

The standard recommended dosage for maca root is 1.5 to 3 grams of dried powder daily, typically taken with meals to improve absorption and reduce gastrointestinal discomfort. For standardized extracts, a dosage of 450mg to 1500mg daily is common. It is advisable to start with a lower dose to assess tolerance, as higher amounts may cause jitteriness or insomnia in sensitive individuals.

Can maca help with low libido and sexual function?

Yes, improving libido is one of the most well-documented benefits of maca root. Multiple randomized controlled trials (Evidence Level B) have shown that maca supplementation can significantly improve sexual desire in both men and women, independent of changes in testosterone levels. It is widely used as a natural aphrodisiac and for supporting sexual function, often showing effects within several weeks of consistent use.

Who should not take maca root?

Individuals with thyroid conditions should avoid maca or use it with caution, as it contains goitrogens that can interfere with thyroid hormone production. Those with hormone-sensitive conditions, such as breast cancer or endometriosis, should also consult a doctor before use due to maca's potential effects on estrogen levels. People with high blood pressure should monitor their levels, as maca may slightly elevate heart rate in some users.

PubMed-compiled information sheet

This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.

Compiled from 29 PubMed articles · model: gemma4:31b

Summary

Maca (Lepidium meyenii) is a root native to the Andean region used as a functional food and medicinal herb for its purported effects on fertility, sexual function, and neuroprotection [PMID:31951246, PMID:41596907].

Background

Maca is a biennial herbaceous plant of the Brassicaceae family indigenous to the high altitudes of the Peruvian Andes (3500-5000 m) [PMID:31643869, PMID:38440178]. It is available in various phenotypes distinguished by color, including yellow, black, and red [PMID:20090350, PMID:24718534].

Traditional uses

Historically used for at least 2000 years as a nutrient-dense food and traditional medicine to promote health, wellness, energy, and fertility [PMID:31951246, PMID:31643869]. It has also been used as a tonic to treat anemia, rheumatism, and respiratory disorders [PMID:28811221].

Active compounds

Bioactive constituents include macamides, macaenes, glucosinolates, alkaloids (such as macaridine), polyphenols, sterols, and polysaccharides [PMID:38440178, PMID:31805775, PMID:11754952, PMID:34533247]. Macamides are secondary amides formed during traditional Andean postharvest drying practices [PMID:25817836].

Mechanism of action

Maca-derived extracellular vesicles may ameliorate depression by promoting 5-HT synthesis via modulation of the gut-brain axis [PMID:38867934]. Other reported pharmacological properties include antioxidant, anti-inflammatory, and neuroprotective effects [PMID:38440178, PMID:31951246].

Clinical evidence

Evidence BSexual Desire

Improvement in sexual desire was observed in healthy men after 8 to 12 weeks of treatment (1,500 mg or 3,000 mg), independent of changes in serum testosterone or estradiol levels [PMID:12472620]

Evidence ASemen Quality

Meta-analysis of RCTs failed to show efficacy in increasing sperm concentration compared to placebo, with mixed results regarding sperm motility [PMID:36110519]. Another RCT in infertile men found no significant differences in semen volume, sperm motility, or normal sperm percentage [PMID:32654242].

Evidence AMenopausal Symptoms

Four RCTs demonstrated favorable effects of maca on menopausal symptoms in healthy perimenopausal, early postmenopausal, and late postmenopausal women [PMID:21840656]

Evidence ASexual Dysfunction

Systematic review of RCTs suggested a significant positive effect on sexual dysfunction or sexual desire in healthy menopausal women [PMID:20691074]

Evidence BPhysical Performance

A double-blind crossover study in well-trained male basketball players found that 2000 mg/day of maca for 2 weeks did not significantly improve jump height, shooting accuracy, sprint performance, or blood lactate clearance [PMID:40960048]

Safety & adverse effects

Maca is generally considered safe with rare adverse effects and good human tolerance [PMID:38440178]. It has not been implicated in causing liver injury [PMID:31643869].

Drug interactions

Adaptogens (which include maca) were involved in 9% of adverse events associated with the concomitant use of antidepressants in a retrospective chart review [PMID:37829299].

Evidence summary

Evidence for maca is mixed. While systematic reviews and RCTs suggest benefits for sexual desire and menopausal symptoms, meta-analyses on semen quality and specific RCTs on athletic performance have shown no significant efficacy. Much of the supporting evidence for neuroprotection and anti-inflammatory effects remains preclinical [PMID:38440178, PMID:36110519, PMID:40960048].

PubMed sources

1.PMID: 31951246 (2020) — Medicinal effects of Peruvian maca (Lepidium meyenii): a review. · Food & function
2.PMID: 38440178 (2024) — Exploring the chemical and pharmacological variability of Lepidium meyenii: a comprehensive review of the effects of maca. · Frontiers in pharmacology
3.PMID: 31643869 (2012) — Not All Maca Is Created Equal: A Review of Colors, Nutrition, Phytochemicals, and Clinical Uses. · Nutrients
4.PMID: 38867934 (2023) — Lepidium meyenii Walp (Maca)-derived extracellular vesicles ameliorate depression by promoting 5-HT synthesis via the modulation of gut-brain axis. · iMeta
5.PMID: 12472620 (2002) — Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men. · Andrologia

Maca

Sources & Citations

Calculate a safe dose of Maca

Maca Red

Maca Red

Maca Yellow

⚠️ Not Recommended During Pregnancy or Nursing

1 Known Drug Interaction — Some May Be Serious

Contraindications

Possible Side Effects

What is a herb–drug interaction?

Known Drug Interactions (1)

Frequently asked questions

Summary

Background

Traditional uses

Active compounds

Mechanism of action

Clinical evidence

Safety & adverse effects

Drug interactions

Evidence summary

PubMed sources

Government sources

Maca

Sources & Citations

Calculate a safe dose of Maca

Related Herbs

Maca Red

Maca Red

Maca Yellow

⚠️ Not Recommended During Pregnancy or Nursing

1 Known Drug Interaction — Some May Be Serious

Contraindications

Possible Side Effects

What is a herb–drug interaction?

Known Drug Interactions (1)

Frequently asked questions

Summary

Background

Traditional uses

Active compounds

Mechanism of action

Clinical evidence

Safety & adverse effects

Drug interactions

Evidence summary

PubMed sources

Government sources