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⚠️ Non recommandé pendant la grossesse ou l'allaitement
Cette plante n'est PAS recommandée pendant la grossesse en raison de risques potentiels pour le fœtus en développement.
Cette plante n'est PAS recommandée pendant l'allaitement car les effets sur les nourrissons sont inconnus.
Consultez votre professionnel de santé avant l'utilisation.
2 interactions médicamenteuses connues — Certaines peuvent être graves
2 Modéré
Cette plante peut interagir avec les médicaments que vous prenez. Consultez le tableau des interactions ci-dessous et parlez-en à votre professionnel de santé avant l'utilisation.
Qu'est-ce qu'une interaction plante-médicament ?
Une interaction plante-médicament se produit lorsqu'une plante ou un complément modifie l'action d'un médicament dans votre organisme — en le rendant plus puissant, moins efficace, ou plus susceptible de provoquer des effets nocifs. Les plantes contiennent des composés actifs qui peuvent accélérer ou ralentir les enzymes et transporteurs utilisés pour métaboliser les médicaments.
Pourquoi c'est important
•Millepertuis peut rendre la contraception, les antidépresseurs et les anticoagulants moins efficaces.
•Ail peut augmenter le risque de saignement avec la warfarine et autres anticoagulants (aussi ginkgo, gingembre et curcuma).
•Kava peut amplifier la sédation avec les médicaments contre l'anxiété ou le sommeil (aussi la valériane).
Le risque est plus élevé chez les personnes âgées, ceux qui prennent plusieurs médicaments et les personnes atteintes de maladies chroniques.
Indiquez toujours à votre médecin et à votre pharmacien toutes les plantes et compléments que vous prenez — et vérifiez ci-dessous avant toute association.
Interactions Médicamenteuses Connues (2)
2 Modéré
Médicament
Sévérité
Description
Pentobarbital
Modéré
La basilic sacré peut renforcer et prolonger les effets sédatifs des barbituriques.
Anticoagulants (Warfarin)
Modéré
Le basilic sacré peut avoir des effets anti-plaquetaires qui augmentent le risque de saignement avec des médicaments anticoagulants.
Cette liste reflète un sous-ensemble sélectionné d'interactions documentées et n'est pas exhaustive. L'absence d'un médicament ici ne prouve pas qu'il est sans danger à combiner. Confirmez toujours auprès d'un pharmacien ou d'un professionnel de santé.
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : glm-5.2
Résumé
Holy Basil (Ocimum tenuiflorum, synonym O. sanctum), also known as Tulsi, is a medicinal herb revered in Ayurveda with demonstrated adaptogenic, antimicrobial, anti-inflammatory, anticancer, and immunomodulatory properties supported by preclinical and limited clinical evidence [PMID:25624701, PMID:28400848].
Contexte
Ocimum tenuiflorum, commonly known as Holy Basil or Tulsi, is a fragrant herbaceous plant belonging to the Lamiaceae family, indigenous to the Indian continent and widely cultivated in India, several Arab countries, West Africa, and tropical regions of the Eastern World [PMID:39771214, PMID:28400848, PMID:36200220]. It is revered in Ayurveda as the 'Elixir of Life' and is believed to promote longevity and general wellbeing [PMID:36185698, PMID:39771214]. Tulsi is preeminent among Ayurvedic herbs and has been utilized since ancient times in the management of a large number of diseases [PMID:25624701, PMID:37567911].
Usages traditionnels
In traditional systems of medicine including Ayurveda, Unani, and Siddha, different parts of O. sanctum (leaves, stem, flower, root, seeds, and whole plant) have been recommended for the treatment of bronchitis, bronchial asthma, malaria, diarrhea, dysentery, skin diseases, arthritis, painful eye diseases, chronic fever, and insect bite [PMID:16170979]. Tulsi has also been traditionally used in Ayurveda for menstrual irregularities, polycystic ovary syndrome (PCOS), infertility, and menopausal symptoms [PMID:38558676]. It has been used as a functional food ingredient in bakery products, dairy products, and beverages such as tea [PMID:38351693].
Composés actifs
Key phytochemicals identified in Holy Basil include eugenol (1-hydroxy-2-methoxy-4-allylbenzene), rosmarinic acid, apigenin, myretenal, luteolin, β-sitosterol, carnosic acid, oleanolic acid, ursolic acid, limonene, camphor, eucalyptol, alpha-bisabolene, beta-bisabolene, beta-caryophyllene, orintin, and vicenin [PMID:23682780, PMID:39473808, PMID:36770859, PMID:16170979]. The plant is also rich in polyphenols, flavonoids, essential oils, and triterpenoids [PMID:40944265, PMID:35578854]. Eugenol is considered the active constituent largely responsible for the therapeutic potentials of Tulsi [PMID:16170979].
Mécanisme d'action
Tulsi acts as an adaptogen, aiding the body in adapting to stress by harmonizing various bodily systems [PMID:39771214]. Its phytochemicals mediate anticancer effects by increasing antioxidant activity, altering gene expressions, inducing apoptosis, and inhibiting angiogenesis and metastasis [PMID:23682780]. Polyphenols present in O. sanctum activate apoptotic signaling, cause cell cycle arrest, bind with membrane receptors, and affect immunomodulation and epigenetic mechanisms [PMID:35578854]. Eugenol exhibits antioxidant, antimicrobial, anesthetic, anti-inflammatory, neuroprotective, anti-diabetic, and anti-cancer activities [PMID:34218781]. Tulsi has been shown to protect organs and tissues against chemical stress from industrial pollutants and heavy metals, physical stress from prolonged physical exertion, ischemia, physical restraint, and exposure to cold and excessive noise, and to counter metabolic stress through normalization of blood glucose, blood pressure, and lipid levels [PMID:25624701].
Preuves cliniques
Preuve BStress, mood, and sleep
An 8-week randomized, double-blind, placebo-controlled trial (n=100) found that 125 mg of a standardized Ocimum tenuiflorum extract (Holixer™) twice daily improved subjective and objective measures of stress and sleep quality in adults experiencing stress, including Perceived Stress Scale, Profile of Mood States, Athens Insomnia Scale, and Restorative Sleep Questionnaire outcomes [PMID:36185698].
Preuve AHPA axis modulation
A systematic review of randomized controlled human trials assessed the effects of single plants or phytonutrients on HPA-axis related hormones, identifying 52 studies examining effects on cortisol, cortisone, corticotrophin-releasing hormone, or adrenocorticotropic hormone [PMID:33650944].
Preuve AMetabolic disorders, cardiovascular disease, immunity, and neurocognition
A systematic review of human studies identified 24 studies reporting therapeutic effects of tulsi on metabolic disorders, cardiovascular disease, immunity, and neurocognition, with all studies reporting favourable clinical outcomes [PMID:28400848].
Preuve CCancer prevention and treatment
Multiple reviews report that Tulsi and its phytochemicals (eugenol, rosmarinic acid, apigenin, luteolin, β-sitosterol, carnosic acid) prevented chemical-induced skin, liver, oral, and lung cancers in preclinical studies through antioxidant activity, altered gene expressions, apoptosis induction, and inhibition of angiogenesis and metastasis [PMID:23682780, PMID:23629478, PMID:34331753, PMID:35578854, PMID:36770859].
Sécurité et effets indésirables
A systematic review of human studies on tulsi's clinical efficacy and safety identified 24 studies reporting favourable clinical outcomes, though specific adverse event details from the review abstract are limited [PMID:28400848]. Reviews note that O. sanctum has been suggested to possess antifertility effects among its various pharmacological actions [PMID:16170979]. One review on cancer treatment noted that Ocimum sanctum may be helpful to many patients with few to no adverse events [PMID:34331753].
Grossesse et allaitement
O. sanctum has been suggested to possess antifertility properties based on traditional and pharmacological reports [PMID:16170979]. No specific data on safety during lactation are available from the provided abstracts.
Posologie et administration
In a randomized controlled trial, 125 mg of a standardized Ocimum tenuiflorum extract (Holixer™) was administered twice daily for 8 weeks to adults experiencing stress [PMID:36185698]. No other specific dosage data available from the provided abstracts. Consult a healthcare provider.
Synthèse des preuves
The evidence base for Holy Basil includes two systematic reviews (one of 24 human clinical studies showing favourable outcomes across metabolic disorders, cardiovascular disease, immunity, and neurocognition; one on HPA axis modulation across 52 studies), one randomized double-blind placebo-controlled trial on stress and sleep, and numerous narrative reviews supporting preclinical pharmacological activities including anticancer, antimicrobial, neuroprotective, and radioprotective effects. Overall, clinical evidence is emerging but remains limited, with most pharmacological support derived from preclinical (in vitro and in vivo) studies and traditional use. Higher-quality randomized controlled trials with larger sample sizes are needed to confirm efficacy across indications.
Sources PubMed
1.PMID: 38558676 (2024) — Ayurvedic Herbal Medicines: A Literature Review of Their Applications in Female Reproductive Health. · Cureus
2.PMID: 36185698 (2022) — A randomized, double-blind, placebo-controlled trial investigating the effects of an Ocimum tenuiflorum (Holy Basil) extract (HolixerTM) on stress, mood, and sleep in adults experiencing stress. · Frontiers in nutrition
3.PMID: 23682780 (2013) — Ocimum sanctum L (Holy Basil or Tulsi) and its phytochemicals in the prevention and treatment of cancer. · Nutrition and cancer
4.PMID: 39473808 (2024) — A Comprehensive Review of the Phytochemical Constituents and Bioactivities of Ocimum tenuiflorum. · TheScientificWorldJournal
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
An in vitro study demonstrated that an O. tenuiflorum and O. gratissimum herbal formulation-based oral rinse exhibited strong antifungal effects against Candida albicans, producing a 13 mm zone of inhibition at 100 µg/mL, outperforming a commercial oral rinse [PMID:39290920].
Preuve DOral pathogens (antimicrobial)
In vitro studies showed that ethanolic extracts of O. tenuiflorum exhibited antimicrobial activity against Streptococcus mutans and Candida albicans [PMID:37082076], and silver nanoparticles synthesized using O. tenuiflorum demonstrated antimicrobial efficacy against oral pathogens [PMID:38550426].
Preuve CPeriodontal disease
A narrative review identified tulsi among various herbs used in the treatment of periodontitis, reporting therapeutic and prophylactic herbal applications in periodontal care [PMID:38290997].
Reviews synthesize experimental evidence that Ocimum sanctum and Ocimum basilicum possess neuroprotective potential in Alzheimer's disease, with bioactive compounds including polyphenols, flavonoids, essential oils, and triterpenoids that synergistically scavenge reactive oxygen species [PMID:40944265]. Another review proposed O. sanctum as a potential immunomodulator for the treatment of ischemic brain injury following stroke [PMID:36515030].
Preuve CCOVID-19 immunity
A literature review examined the role of Ayush Kwath (containing Tulsi/Holy Basil/Ocimum sanctum among other herbs) in improving immunity and combating SARS-CoV-2 infection, as recommended by the Ministry of AYUSH, Government of India [PMID:32837101].
Preuve CFemale reproductive health
A literature review of Ayurvedic herbal medicines examined data regarding the efficacy of Tulsi (Ocimum tenuiflorum) for menstrual irregularities, PCOS, infertility, and menopausal symptoms [PMID:38558676].
Preuve CRadioprotection
A review of radioprotective effects of plants from the Lamiaceae family found that Ocimum tenuiflorum exhibited relatively well-documented preventive properties, with essential oils and complex extracts containing phenolic acids and flavonoids showing radioprotective effectiveness in in vitro and in vivo models [PMID:33121420]. The aqueous extract of Tulsi and its flavonoids orintin and vicenin were shown to protect mice against γ-radiation-induced sickness and mortality [PMID:23682780].
— Modulation of the hypothalamic-pituitary-adrenal (HPA) axis by plants and phytonutrients: a systematic review of human trials.
· Nutritional neuroscience
6.PMID: 28400848 (2017) — The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature. · Evidence-based complementary and alternative medicine : eCAM
7.PMID: 39771214 (2024) — Harnessing the Antibacterial, Anti-Diabetic and Anti-Carcinogenic Properties of Ocimum sanctum Linn (Tulsi). · Plants (Basel, Switzerland)
8.PMID: 38351693 (2024) — Ocimum sanctum: The Journey from Sacred Herb to Functional Food. · Recent advances in food, nutrition & agriculture
9.PMID: 20509321 (2009) — The science behind sacredness of Tulsi (Ocimum sanctum Linn.). · Indian journal of physiology and pharmacology
10.PMID: 23629478 (2013) — Ocimum sanctum Linn. (Tulsi): an ethnomedicinal plant for the prevention and treatment of cancer. · Anti-cancer drugs
11.PMID: 36515030 (2024) — Ocimum sanctum [Tulsi] as a Potential Immunomodulator for the Treatment of Ischemic Injury in the Brain. · Current molecular medicine
12.PMID: 38290997 (2024) — Phytotherapy in periodontics as an effective and sustainable supplemental treatment: a narrative review. · Journal of periodontal & implant science
13.PMID: 35578854 (2022) — Chemotherapeutic Role of Polyphenols Present in Ocimum sanctum. · Anti-cancer agents in medicinal chemistry
14.PMID: 25624701 (2014) — Tulsi - Ocimum sanctum: A herb for all reasons. · Journal of Ayurveda and integrative medicine
15.PMID: 34331753 (2023) — Ocimum Sanctum: An All-Round Treatment for Cancer? · Alternative therapies in health and medicine
16.PMID: 36200220 (2023) — A Glance at the Phytochemical and Ethno-pharmacological Understanding of Four Ocimum Species. · Current pharmaceutical biotechnology
17.PMID: 37567911 (2023) — Characterizing the circadian connectome of Ocimum tenuiflorum using an integrated network theoretic framework. · Scientific reports
18.PMID: 37008142 (2023) — Exploring the Chemistry of Ocimum Species under Specific Extractions and Chromatographic Methods: A Systematic Review. · ACS omega
19.PMID: 33121420 (2022) — Radioprotective Effects of Plants from the Lamiaceae Family. · Anti-cancer agents in medicinal chemistry
20.PMID: 36770859 (2023) — An Update on the Therapeutic Anticancer Potential of Ocimum sanctum L.: "Elixir of Life". · Molecules (Basel, Switzerland)
21.PMID: 16170979 (2005) — Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its pharmacological actions: a short review. · Indian journal of physiology and pharmacology
22.PMID: 32837101 (2022) — Immunity against COVID-19: Potential role of Ayush Kwath. · Journal of Ayurveda and integrative medicine
23.PMID: 40944265 (2025) — The Neuroprotective Potential of Ocimum Plant Species: Seasoning the Mind with Sweet and Holy Basil. · Nutrients
24.PMID: 39290920 (2024) — Antifungal Activity of Ocimum tenuiflorum and Ocimum gratissimum Herbal Formulation-Based Oral Rinse Against Candida albicans. · Cureus
25.PMID: 37082076 (2022) — Antimicrobial efficiency of Tinospora cordifolia and Ocimum tenuiflorum against Streptococcus mutans and Candida albicans. · Journal of oral and maxillofacial pathology : JOMFP
26.PMID: 38550426 (2024) — Antimicrobial Activity of Silver Nanoparticles Synthesized Using Ocimum tenuiflorum and Ocimum gratissimum Herbal Formulations. · Cureus
27.PMID: 34218781 (2021) — Eugenol as a Potential Drug Candidate: A Review. · Current topics in medicinal chemistry
28.PMID: 30475878 (2018) — Product authenticity versus globalisation-The Tulsi case. · PloS one