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Severe· well-documented
Avoid this combination unless your prescriber explicitly approves it with appropriate monitoring.
Licorice combined with loop diuretics can cause severe potassium depletion and dangerous hypokalemia.
Additive potassium-wasting effects through different mechanisms: licorice via mineralocorticoid pathway, furosemide via renal tubular effects.
Source: Natural Medicines Database · Reviewed April 2026
Licorice Root + Furosemide (Lasix): high risk. Avoid this combination unless your prescriber explicitly approves it with appropriate monitoring. Licorice combined with loop diuretics can cause severe potassium depletion and dangerous hypokalemia.
Additive potassium-wasting effects through different mechanisms: licorice via mineralocorticoid pathway, furosemide via renal tubular effects.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.