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Severe· well-documented
Avoid this combination unless your prescriber explicitly approves it with appropriate monitoring.
Licorice-induced hypokalemia can increase sensitivity to digoxin toxicity, potentially causing dangerous cardiac arrhythmias.
Glycyrrhizin causes potassium depletion, and low potassium increases myocardial sensitivity to digoxin toxicity.
Source: Natural Medicines Database · Reviewed April 2026
Licorice Root + Digoxin: high risk. Avoid this combination unless your prescriber explicitly approves it with appropriate monitoring. Licorice-induced hypokalemia can increase sensitivity to digoxin toxicity, potentially causing dangerous cardiac arrhythmias.
Glycyrrhizin causes potassium depletion, and low potassium increases myocardial sensitivity to digoxin toxicity.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.