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Moderate· moderate-evidence
May be possible under supervision — talk to your prescriber or pharmacist before combining.
Licorice may increase prednisolone levels by inhibiting its metabolism, enhancing both therapeutic effects and side effects.
Glycyrrhizin inhibits 11-beta-hydroxysteroid dehydrogenase, slowing the conversion of prednisolone to inactive prednisone.
Source: Clinical Studies · Reviewed April 2026
Licorice Root + Prednisolone: use caution. May be possible under supervision — talk to your prescriber or pharmacist before combining. Licorice may increase prednisolone levels by inhibiting its metabolism, enhancing both therapeutic effects and side effects.
Glycyrrhizin inhibits 11-beta-hydroxysteroid dehydrogenase, slowing the conversion of prednisolone to inactive prednisone.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.