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Severe· well-documented
Avoid this combination unless your prescriber explicitly approves it with appropriate monitoring.
Licorice may counteract the effects of spironolactone, reducing its blood pressure-lowering and potassium-sparing effects.
Licorice's mineralocorticoid effects directly oppose spironolactone's aldosterone antagonism.
Source: WHO Monographs · Reviewed April 2026
Licorice Root + Spironolactone: high risk. Avoid this combination unless your prescriber explicitly approves it with appropriate monitoring. Licorice may counteract the effects of spironolactone, reducing its blood pressure-lowering and potassium-sparing effects.
Licorice's mineralocorticoid effects directly oppose spironolactone's aldosterone antagonism.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.