Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
⚠️ Non recommandé pendant la grossesse ou l'allaitement
Cette plante n'est PAS recommandée pendant la grossesse en raison de risques potentiels pour le fœtus en développement.
Cette plante n'est PAS recommandée pendant l'allaitement car les effets sur les nourrissons sont inconnus.
Consultez votre professionnel de santé avant l'utilisation.
3 interactions médicamenteuses connues — Certaines peuvent être graves
3 Modéré
Cette plante peut interagir avec les médicaments que vous prenez. Consultez le tableau des interactions ci-dessous et parlez-en à votre professionnel de santé avant l'utilisation.
Qu'est-ce qu'une interaction plante-médicament ?
Une interaction plante-médicament se produit lorsqu'une plante ou un complément modifie l'action d'un médicament dans votre organisme — en le rendant plus puissant, moins efficace, ou plus susceptible de provoquer des effets nocifs. Les plantes contiennent des composés actifs qui peuvent accélérer ou ralentir les enzymes et transporteurs utilisés pour métaboliser les médicaments.
Pourquoi c'est important
•Millepertuis peut rendre la contraception, les antidépresseurs et les anticoagulants moins efficaces.
•Ail peut augmenter le risque de saignement avec la warfarine et autres anticoagulants (aussi ginkgo, gingembre et curcuma).
•Kava peut amplifier la sédation avec les médicaments contre l'anxiété ou le sommeil (aussi la valériane).
Le risque est plus élevé chez les personnes âgées, ceux qui prennent plusieurs médicaments et les personnes atteintes de maladies chroniques.
Indiquez toujours à votre médecin et à votre pharmacien toutes les plantes et compléments que vous prenez — et vérifiez ci-dessous avant toute association.
Le black cohosh a été associé à des cas rares de dommage hépatique. La combinaison avec d'autres médicaments hépatotoxiques peut augmenter le risque de lésion hépatique.
De rares cas d'atteinte hépatique ont été rapportés avec l'actée à grappes noires, et l'associer à l'atorvastatine (qui comporte aussi un risque hépatique) justifie une surveillance de la fonction hépatique.
Cette liste reflète un sous-ensemble sélectionné d'interactions documentées et n'est pas exhaustive. L'absence d'un médicament ici ne prouve pas qu'il est sans danger à combiner. Confirmez toujours auprès d'un pharmacien ou d'un professionnel de santé.
How does black cohosh work to relieve menopause symptoms?
Black cohosh's exact mechanism remains under investigation, though it is believed to act on serotonin receptors rather than estrogen receptors. Research suggests compounds like triterpene glycosides may modulate neurotransmitters involved in thermoregulation. Unlike phytoestrogens, it does not appear to stimulate breast tissue, making it distinct from hormonal therapies (Evidence Level: B).
Can black cohosh interact with medications or hormone therapy?
Black cohosh may interact with hormone-sensitive conditions and medications metabolized by the liver. It is contraindicated for patients with hormone-sensitive cancers or those taking CYP450 substrates due to potential liver enzyme interactions. Patients on anticoagulants or hormone replacement therapy should consult a physician before use (Evidence Level: C/D).
What is the recommended dosage for black cohosh extract?
The standard adult dosage for black cohosh is 20 to 40 mg of a standardized extract (containing triterpene glycosides) taken twice daily. Clinical studies often utilize specific extracts like Remifemin. Users should not exceed recommended durations without medical supervision, typically limiting use to six months (Evidence Level: B).
Is black cohosh safe to take during pregnancy or breastfeeding?
Black cohosh is considered unsafe during pregnancy because it can stimulate uterine contractions and induce labor. While traditionally used for this purpose near term, it should be avoided earlier in pregnancy to prevent miscarriage. It is also not recommended during breastfeeding due to insufficient safety data and potential toxicity to the infant (Evidence Level: C/D).
Is black cohosh effective for treating hot flashes and night sweats?
Clinical studies suggest black cohosh may reduce the frequency and severity of hot flashes and night sweats associated with menopause (Evidence Level: B). While results have been mixed, meta-analyses often show modest benefits compared to placebo. It is considered one of the most researched herbs for menopausal symptom management, though individual responses vary significantly.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 25 articles PubMed · modèle : gemma4:31b
Résumé
Black cohosh (Actaea racemosa) is a North American botanical supplement primarily used to manage menopausal symptoms [PMID:29261886, PMID:31643322].
Contexte
Black cohosh, also known as Cimicifuga racemosa, is a perennial dicot of the Buttercup (Ranunculaceae) family native to the Eastern United States and Canada [PMID:29261886, PMID:33861455]. It is also referred to as baneberry, black snakeroot, bug root, and bugbane [PMID:29261886].
Usages traditionnels
Historically, it has been used by indigenous populations for rheumatoid muscular pain, headache, inflammation, dysmenorrhea, premenstrual syndrome (PMS), and menstrual pain and cramping [PMID:33861455, PMID:22504147]. It has also been used to promote labor [PMID:30000840].
Composés actifs
The rootstock contains triterpene glycosides (including actein, cimicifugoside, and 27-deoxyactein), isoferulic acid, and alkaloids such as n-methylcytisine [PMID:30000840, PMID:18592868].
Mécanisme d'action
While historically thought to have estrogenic activity, recent studies suggest it does not bind to estrogen receptors and lacks estrogenic effects on mammary cancer cells in vitro or uterine histology in rats [PMID:30000840, PMID:23459142]. Some research suggests it may act as an antinociceptive agent [PMID:22504147].
Preuves cliniques
Preuve AMenopausal symptoms (neurovegetative and psychological)
Isopropanolic extract (iCR) was significantly superior to placebo and comparable in efficacy to low-dose transdermal estradiol or tibolone, with a better benefit-risk profile than tibolone [PMID:33021111].
Preuve BMenopausal symptoms (combined therapy)
A combination of Black Cohosh, Soy Isoflavones, and SDG Lignans showed significant improvements in somatic, psychological, and urogenital domains compared to placebo [PMID:40131516].
Preuve CClimacteric complaints
The extract CR BNO 1055 reduced major climacteric complaints as effectively as conjugated estrogens and significantly more than placebo [PMID:23459142].
Preuve AHot flashes in breast cancer patients
Research assessing efficacy for the treatment of hot flashes in women with breast cancer is inconclusive [PMID:17602247].
Sécurité et effets indésirables
General adverse reactions are low in frequency but may include dizziness, nausea, headache, rash, vomiting, mastalgia, and weight gain [PMID:30000840, PMID:15898823]. Rare but severe reports of acute liver injury, hepatitis, and allergic reactions have occurred [PMID:30000840, PMID:31643322].
Grossesse et allaitement
Historically used by Native American women as a galactogogue, but there is no current data on safety and efficacy in nursing mothers or infants; some sources recommend against use during breastfeeding due to lack of safety data [PMID:30000840].
Interactions médicamenteuses
Black cohosh is reported to have a low likelihood of drug interactions and can generally be safely taken with most medications [PMID:28762712].
Posologie et administration
One review notes a current recommended dosage of 40-80 mg/day for certain extracts [PMID:15898823]. No PubMed data available. Consult a healthcare provider.
Synthèse des preuves
Evidence for the treatment of menopausal symptoms is supported by meta-analyses and RCTs, though some reviews describe findings as inconsistent or methodology as poor. Safety is generally high for short-term use, though rare hepatotoxicity is noted.
Sources PubMed
1.PMID: 28762712 (2017) — Common Herbal Dietary Supplement-Drug Interactions. · American family physician
2.PMID: 39477563 (2024) — Complementary and Alternative Medicine for Menopause. · The Nursing clinics of North America
3.PMID: 30000840 (2006) — Exploring the Efficacy and Safety of Black Cohosh (Cimicifuga racemosa) in Menopausal Symptom Management. · Journal of mid-life health
4.PMID: 31643322 (2012) — Botanicals and Their Bioactive Phytochemicals for Women's Health. · CITED REFERENCES
5.PMID: 29261886 (2026) — Black cohosh. · American family physician
— A review of effective herbal medicines in controlling menopausal symptoms.
· Electronic physician
7.PMID: 33021111 (2021) — Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms - an update on the evidence. · Climacteric : the journal of the International Menopause Society
8.PMID: 30725649 (2026) — Gynecology: select topics. · Primary care
9.PMID: 40131516 (2025) — Assessing the combined effects of Black Cohosh, Soy Isoflavones, and SDG Lignans on menopausal symptoms: a randomized, double-blind, placebo-controlled clinical trial. · European journal of nutrition
10.PMID: 15500420 (2004) — The safety of black cohosh (Actaea racemosa, Cimicifuga racemosa). · Expert opinion on drug safety
11.PMID: 15898823 (2005) — Black cohosh (Actaea/Cimicifuga racemosa): review of the clinical data for safety and efficacy in menopausal symptoms. · Treatments in endocrinology
12.PMID: 33926292 (2022) — Systematic Review of Black Cohosh (Cimicifuga racemosa) for Management of Polycystic Ovary Syndrome-Related Infertility. · Journal of pharmacy practice
13.PMID: 35020295 (2002) — Is black cohosh estrogenic? · Nutrition reviews
14.PMID: 22972105 (2012) — Black cohosh (Cimicifuga spp.) for menopausal symptoms. · The Cochrane database of systematic reviews
15.PMID: 23459142 (2014) — The non-estrogenic alternative for the treatment of climacteric complaints: Black cohosh (Cimicifuga or Actaea racemosa). · The Journal of steroid biochemistry and molecular biology
16.PMID: 33861455 (2021) — Ethnobotany, Phytochemistry, Traditional and Modern Uses of Actaea racemosa L. (Black cohosh): A Review. · Advances in experimental medicine and biology
17.PMID: 35337076 (2022) — Benefits of Black Cohosh (Cimicifuga racemosa) for Women Health: An Up-Close and In-Depth Review. · Pharmaceuticals (Basel, Switzerland)
18.PMID: 18592868 (2008) — [Efficacy and safety of Black cohosh (Actaea/Cimicifuga racemosa) in the treatment of vasomotor symptoms--review of clinical trials]. · Ginekologia polska
19.PMID: 22504147 (2012) — Black cohosh: coming full circle? · Journal of ethnopharmacology
20.PMID: 17602247 (2007) — Black cohosh (Cimicifuga racemosa [L.] Nutt.): safety and efficacy for cancer patients. · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
21.PMID: 18585461 (2008) — Black cohosh (Cimicifuga racemosa) for menopausal symptoms: a systematic review of its efficacy. · Pharmacological research