Feverfew (Tanacetum parthenium): Benefits, Dosage, Safety & Evidence

Qu'est-ce qu'une interaction plante-médicament ?

Une interaction plante-médicament se produit lorsqu'une plante ou un complément modifie l'action d'un médicament dans votre organisme — en le rendant plus puissant, moins efficace, ou plus susceptible de provoquer des effets nocifs. Les plantes contiennent des composés actifs qui peuvent accélérer ou ralentir les enzymes et transporteurs utilisés pour métaboliser les médicaments.

Pourquoi c'est important

Millepertuis peut rendre la contraception, les antidépresseurs et les anticoagulants moins efficaces.

Ail peut augmenter le risque de saignement avec la warfarine et autres anticoagulants (aussi ginkgo, gingembre et curcuma).

Kava peut amplifier la sédation avec les médicaments contre l'anxiété ou le sommeil (aussi la valériane).

Le risque est plus élevé chez les personnes âgées, ceux qui prennent plusieurs médicaments et les personnes atteintes de maladies chroniques.

Indiquez toujours à votre médecin et à votre pharmacien toutes les plantes et compléments que vous prenez — et vérifiez ci-dessous avant toute association.

Interactions Médicamenteuses Connues (3)

2 Modéré1 Léger

Médicament	Sévérité	Description
NSAIDs (Ibuprofen)	Léger	La grande camomille peut avoir des effets antiplaquettaires additifs avec les AINS, augmentant potentiellement le risque de saignement.
Aspirin	Modéré	La grande camomille (parthénolide) inhibe l'agrégation plaquettaire et la libération de sérotonine par les plaquettes, s'ajoutant à l'effet de l'aspirine et augmentant le risque de saignement.
Warfarin (Coumadin)	Modéré	La Grande camomille pourrait augmenter le risque de saignement lorsqu'elle est combinée avec la warfarine en raison de ses effets antiplaquettaires.

Cette liste reflète un sous-ensemble sélectionné d'interactions documentées et n'est pas exhaustive. L'absence d'un médicament ici ne prouve pas qu'il est sans danger à combiner. Confirmez toujours auprès d'un pharmacien ou d'un professionnel de santé.

Questions fréquentes

How does feverfew work to prevent migraines?

Feverfew's primary active compound, parthenolide, works by inhibiting serotonin release from platelets and preventing blood vessel constriction in the brain. Parthenolide also blocks nuclear factor-kappa B (NF-κB), reducing inflammatory prostaglandin production. These combined actions help prevent the inflammatory cascade that triggers migraine headaches. Clinical evidence supports this mechanism, earning feverfew a Level B evidence rating for migraine prevention.

Does feverfew interact with blood thinners or other medications?

Yes, feverfew can interact with several medications. Because it inhibits platelet aggregation, feverfew should not be combined with anticoagulant or antiplatelet medications such as warfarin, aspirin, clopidogrel, or NSAIDs, as this increases bleeding risk. Feverfew may also affect medications metabolized by the liver's cytochrome P450 enzyme system. Always consult a healthcare provider before combining feverfew with prescription medications.

What is the recommended dosage of feverfew for migraine prevention?

For migraine prevention, the standard adult dosage is 50-100mg of dried feverfew leaf daily, or supplements standardized to provide 6.25mg of parthenolide daily. Consistency is important—feverfew must be taken regularly for at least 1-2 months to evaluate effectiveness. Avoid abrupt discontinuation, as this can cause rebound headaches. Always follow product label instructions or consult a qualified healthcare practitioner for personalized dosing.

Is feverfew safe to take during pregnancy or breastfeeding?

No, feverfew is considered unsafe during pregnancy and breastfeeding. The herb can stimulate uterine contractions, potentially causing miscarriage or premature labor. There is insufficient safety data for breastfeeding, so avoidance is recommended. Women who are pregnant, trying to conceive, or breastfeeding should not use feverfew. Additionally, discontinue feverfew at least two weeks before scheduled surgery due to bleeding risks.

What is feverfew used for besides migraines?

Feverfew has been used traditionally since ancient Greek times for fever reduction, headache treatment, arthritis relief, and menstrual pain. Modern research has primarily focused on migraine prevention, where clinical trials have shown promising results with a Level B evidence rating. Some preliminary research suggests potential anti-inflammatory benefits for arthritis, though evidence remains limited. Fresh leaves were historically chewed for headache relief.

What are the side effects of taking feverfew?

Common side effects include gastrointestinal upset, bloating, and mouth ulcers—particularly when chewing fresh leaves. Allergic reactions can occur, especially in individuals sensitive to the Asteraceae (daisy) family. Abrupt discontinuation after regular use may cause rebound headaches. Some users report temporary mouth tingling. Serious adverse effects are rare, but anyone experiencing allergic symptoms should discontinue use and seek medical attention.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 27 articles PubMed · modèle : gemma4:31b

Résumé

Feverfew (Tanacetum parthenium) is a medicinal herb most commonly used for the prophylaxis of migraine headaches [PMID:30000921].

Contexte

Feverfew (Tanacetum parthenium) is a plant from the Asteraceae family with a long history of use in traditional and folk medicine, particularly among early European and Greek herbalists [PMID:22096324].

Usages traditionnels

Traditionally used for fevers, migraine headaches, rheumatoid arthritis, stomach aches, toothaches, insect bites, infertility, problems with menstruation and labor during childbirth, psoriasis, allergies, asthma, tinnitus, dizziness, nausea, and vomiting [PMID:22096324].

Composés actifs

The principal active ingredient is thought to be the sesquiterpene lactone parthenolide [PMID:30000921, PMID:31763637]. Other potentially active constituents include flavonoid glycosides and pinenes [PMID:22096324].

Mécanisme d'action

Parthenolide exhibits anti-inflammatory, redox-modulating, and epigenetic activities [PMID:31763637]. It inhibits the release of pro-inflammatory mediators from macrophages and lymphocytes [PMID:22761185] and may suppress STAT3/NF-κB and inflammasome activation [PMID:35729839].

Preuves cliniques

Preuve AMigraine Prophylaxis

Evidence for efficacy is mixed [PMID:32310327, PMID:30627973], although some systematic reviews indicate the majority of trials favor feverfew over placebo [PMID:11276299] and other reviews describe the evidence as promising [PMID:24682554].

Preuve CInflammatory Skin Conditions

Feverfew is noted for anti-inflammatory and antioxidant properties that may be useful for treating inflammatory skin dermatoses and photoaging [PMID:18681154, PMID:25226001].

Sécurité et effets indésirables

Generally well tolerated in adults, though occasional gastrointestinal irritation or oral ulcers may occur [PMID:30000921]. Rapid discontinuation may lead to rebound headaches [PMID:30000921]. Rare allergic reactions can occur, including cross-reactions to daisies, marigolds, and chrysanthemums [PMID:30000921]; it is also identified as a cause of allergic contact dermatitis [PMID:18021597].

Grossesse et allaitement

There is no data on the safety and efficacy of feverfew in nursing mothers or infants, nor on the excretion of its components into breastmilk; consequently, some reviewers recommend against its use during breastfeeding [PMID:30000921].

Synthèse des preuves

The evidence for migraine prophylaxis is the most extensively studied but remains mixed across systematic reviews. Preclinical data suggest strong anti-inflammatory and neuroprotective properties of its active compound, parthenolide.

Sources PubMed

1.PMID: 30000921 (2006) — Migraine Headache Prophylaxis. · American family physician
2.PMID: 32310327 (2020) — Herbal treatments for migraine: A systematic review of randomised-controlled studies. · Phytotherapy research : PTR
3.PMID: 39265445 (2024) — Parthenolide attenuates hypoxia-induced pulmonary hypertension through inhibiting STAT3 signaling. · Phytomedicine : international journal of phytotherapy and phytopharmacology
4.PMID: 35729839 (2022) — Parthenolide ameliorates neurological deficits and neuroinflammation in mice with traumatic brain injury by suppressing STAT3/NF-κB and inflammasome activation. · International immunopharmacology
5.PMID: 12793186 (2003) — [Compositae dermatitis]. · Medicinski pregled

Feverfew

Sources et citations

Calculer une dose sûre de Feverfew

White Willow

Devil's Claw

Butterbur

⚠️ Non recommandé pendant la grossesse ou l'allaitement

3 interactions médicamenteuses connues — Certaines peuvent être graves

Contre-indications

Effets secondaires possibles

Qu'est-ce qu'une interaction plante-médicament ?

Interactions Médicamenteuses Connues (3)

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Grossesse et allaitement

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Feverfew

Sources et citations

Calculer une dose sûre de Feverfew

Plantes associées

White Willow

Devil's Claw

Butterbur

⚠️ Non recommandé pendant la grossesse ou l'allaitement

3 interactions médicamenteuses connues — Certaines peuvent être graves

Contre-indications

Effets secondaires possibles

Qu'est-ce qu'une interaction plante-médicament ?

Interactions Médicamenteuses Connues (3)

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Grossesse et allaitement

Synthèse des preuves

Sources PubMed

Sources gouvernementales